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If you use a computer for long periods of time every day, a suitable ergonomic mouse can indeed reduce the fatigue caused by your wrist being suspended and twisted for extended periods.

Especially for those who frequently work at a desk, edit photos, or cut videos, wrist discomfort from prolonged use of a regular mouse and touchpad is often more pronounced. Of course, it can’t replace treatment, but a more natural grip can at least make daily tasks easier.

To identify truly worthwhile products, we tested nine different ergonomic mice and compared them based on factors such as grip comfort, button feel, control performance, and ease of use. Ultimately, we selected only two: one more suitable for most users’ daily office work, and the other a vertical mouse that emphasizes a natural wrist posture, suitable for those with higher comfort requirements.

Best Ergonomic Mouse: Logitech MX Master 4

Of the nine ergonomic mice I tested, the Logitech MX Master 4 is the one I consider to have the highest overall quality. It’s certainly not cheap, but once you actually use it, you’ll find it’s not just an ordinary office mouse; it excels in grip comfort, operational efficiency, and attention to detail.

The MX Master 4’s body curvature has been refined over the years, allowing the palm, knuckles, and fingers to fit naturally when placed on it. The index and middle fingers rest comfortably on the left and right buttons, and the scroll wheel is also conveniently positioned, eliminating the need for conscious adjustment of the grip. More importantly, it provides excellent support for the thumb, ring finger, and little finger, ensuring that the palm doesn’t remain suspended during extended use, and the fingers don’t need to grip the mouse forcefully.

I think the most interesting upgrade in this generation is the addition of the Haptic Sense Panel to the thumb area. It provides feedback through slight vibrations during operation, such as moving the cursor across screens, switching functions, or completing an action, offering a clearer sense of confirmation. For those who frequently use dual or multiple screens, this feedback definitely reduces the chances of the cursor “losing.”

Tapping this area brings up the Action Ring, concentrating frequently used operations near the cursor. Whether opening bookmarked web pages, adjusting media playback, or accessing application shortcuts, there’s no need for frequent mouse movements. Combined with the side scroll wheel and three customizable buttons, efficiency is significantly improved when working with tables, editing timelines, or browsing multiple windows.

The MX Master 4’s main scroll wheel still supports both high-speed scrolling and segmented scrolling modes. When viewing long web pages or large documents, you can quickly scroll to the bottom; when you need finer operations, you can switch to clear segmented scrolling. The horizontal scroll wheel is also very useful, eliminating the need to drag the bottom scroll bar when working with Excel, video timelines, and wide pages.

In terms of materials, it uses a more solid metal top cover and anti-slip side skirts, giving it a more premium feel than ordinary plastic mice. The damping and feedback of the two scroll wheels are also very clear, without feeling loose. Although the body is on the heavier side, it is actually more stable when used on a desk, and slight movements are less likely to affect cursor control.

In terms of connectivity, the MX Master 4 supports Windows, macOS, Linux, ChromeOS, iPadOS, and Android, and can save data on three devices simultaneously, allowing for quick switching via the bottom button. With Logi Options+, almost all buttons can be reconfigured, and individual shortcuts can be assigned to different software such as Photoshop, Zoom, and browsers.

Logitech has also switched to a USB-C receiver this time, making it more compatible with laptops that now only have USB-C ports. The mouse has a built-in rechargeable battery with a claimed battery life of up to 70 days and supports charging while in use. Based on my usage, it doesn’t really need frequent charging, and I don’t have to worry about running out of power during long hours of office work.

Of course, it’s not without its drawbacks. The size is on the larger side, which might not fit users with smaller hands perfectly, and the weight isn’t suitable for those who frequently lift their mouse. Additionally, Logitech hasn’t yet released a left-handed version. Even so, if you use your computer for long hours every day and are willing to invest more in comfort and efficiency, the MX Master 4 remains one of the most worthwhile ergonomic mice to consider.

Best vertical ergonomic mouse: Logitech Lift

Of the several vertical mice I’ve tested, the Logitech Lift is the one I think is best suited for most users. Its advantages aren’t just its relatively affordable price, but more importantly, its natural grip and ease of adaptation. Even those who have never used a vertical mouse before can usually find a comfortable way to apply force in a short time.

The Lift features a 57-degree tilt design, so when you place your palm on it, it no longer hangs completely downwards like a regular mouse, but maintains a near-handshake posture. The thumb rests on the side, and the other fingers naturally wrap around the body. Movement is primarily driven by the forearm and palm, resulting in less wrist twisting. For me, its most noticeable benefit is that my wrist doesn’t tighten as easily after prolonged use.

However, the Lift is more suitable for small to medium-sized hands. Its body isn’t particularly large, and users with larger hands might find it lacks sufficient support. In such cases, the larger MX Vertical would be a better fit. It’s commendable that the Lift offers both left- and right-handed versions, and is available in white, graphite gray, and pink, which is more considerate than many vertical mice that only cater to right-handed users.

In terms of functionality, it offers a total of six buttons, including left and right main buttons, a clickable scroll wheel, two thumb side buttons, and a sensitivity adjustment button below the scroll wheel. These buttons can be reconfigured via Logi Options+ to control volume, switch pages, or access frequently used shortcuts, which is sufficient for daily office work.

The connectivity options are also quite flexible, supporting both Bluetooth and the Logi Bolt USB-A receiver. It can save data for up to three devices, allowing for quick switching between them with a press of the bottom button, which is convenient when using a laptop, tablet, and another computer simultaneously on a desktop.

My biggest complaint about the Lift is that it still uses a single AA battery, meaning it can’t be charged via USB-C or used while charging. However, its battery life is indeed very long; the official claim is that a single battery can last up to two years, meaning it doesn’t need frequent replacements under normal circumstances. But looking at it now, I still hope the next generation will have a built-in battery.

Overall, the Logitech Lift is suitable for users who are trying a vertical mouse for the first time, have small to medium-sized hands, and want to balance comfort and practicality. It’s not the most luxurious model, but it does achieve a good balance between grip, ease of use, and full functionality.

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